Selected publications from NRP Scientists working on metabolomics research

Listed below are selected publications in the area of metabolomics/metabolite profiling from:
  • Metabolomics Group - IFR: see our full list of publications on the group webpages.

Last updated July 5, 2011

 

Bioinformatics & Statistics Group at IFR

Rahmioglu N., Le Gall G., Heaton J., Kay K., Smith N., Colquhoun I. J., Ahmadi K., Kemsley E. K.(2011) Prediction of variability in CYP3A4 induction using a combined 1H NMR metabonomics and targeted UPLC/MS approach Journal of Proteome Research. 10 (6) 2807-2816. E-print doi: 10.1021/pr200077n View abstract at PubMed

Pope G.A., MacKenzie D.A., Defernez M. and Roberts I.N. Metabolic footprinting for the study of microbial biodiversity. Submitted to CSH Protocols, January 2009. Download our Perl and Matlab macros described in the protocol (DIMS data pre-processing and basic multivariate analysis).

Tapp H. & Kemsley E. K. Optimizing the efficiency of cross-validation in linear discriminant analysis (LDA) through selective use of the Sherman-Morrison-Woodbury formula. Journal of Chemometrics, 2008, 22 (6), 419 - 421. Download our Matlab code (m-files) for optimized cross-validated LDA and a genetic algorithm for feature subset selection. Example multivariate data sets are included.

Kemsley E. K. , Le Gall G. , Watson A. D. , Harvey L. J. , Tapp H. S., Dainty J. R. & Colquhoun I. J. Multivariate techniques and their application in nutrition: a metabolomics case study. British Journal of Nutrition, 2007, 98 (1) 1-14.

H. Tapp, M. Defernez, and E. K. Kemsley, FTIR spectroscopy and multivariate analysis can distinguish geographical origin of extra virgin olive oil, J. Agric. Food Chem., 2003, 51(21), 6110-6115. Download dataset at the B&S team webpages.

M. Defernez and I.J. Colquhoun, Factors affecting the robustness of metabolite fingerprinting using 1H NMR spectra, Phytochem., 2003, 62, 1009-1017.

M. Defernez and I.J. Colquhoun, NMR approaches to detect unintended effects of genetic modification in plants, in 'Genomics for Biosafety in Plant Biotechnology', Ed. J.-P. Nap, A. Atanassov, W. J. Stiekema, NATO Science Series, IOS Press, Netherlands, 2004 G. Le Gall, I.J. Colquhoun and M. Defernez, Metabolite Profiling Using 1H NMR Spectroscopy for Quality Assessment of Green Tea, Camellia sinensis (L.), J. Agric. Food Chem., 2004, 52, 692-700.

Y.M.Gunning, M.Defernez, N.M.Rigby, A.J.Parr, I.J.Colquhoun. Metabolic profiling techniques for detecting unintended effects of genetic modification. (Poster: pdf file)

Holland, J. K., Kemsley, E. K., & Wilson, R. H. Use of Fourier transform infrared spectroscopy and partial least squares regression for the detection of adulteration of strawberry purees. J. Sci. Food Agric, 1998, 76, 263-269.

Kemsley, E. K., Holland, J. K., Defernez, M., & Wilson, R. H. Detection of adulteration of raspberry purees using infrared spectroscopy and chemometrics J. Agric. Food Chem, 1996, 44, 3864-3870.

Briandet, R., Kemsley, E. K., & Wilson, R. H. Discrimination of Arabica and Robusta in instant coffee by Fourier transform infrared spectroscopy and chemometrics. J. Agric. Food Chem, 1996, 44, 170-174.

L.Chen, N.C.Carpita, W-D Reiter, R.H.Wilson, C.Jeffries and M.C.McCann. A rapid method to screen for cell-wall mutants using discriminant analysis of Fourier transform infrared data. The Plant Journal, 1998, 16(3) 385-392.

M.McCann, M.Bush, D.Milioni, P.Sado, N.J.Stacey, G.Catchpole, M.Defernez, N.C.Carpita, H.Hofte, P.Ulvskov, R.H.Wilson and K.Roberts. Approaches to understanding the functional architecture of the plant cell wall. Phytochemistry 2001, 57, 811-821.

Molecular Phytopathology Group at the Sainsbury Laboratory

Papadopoulou K, Melton RE, Leggett M, Daniels MJ and Osbourn AE., Compromised disease resistance in saponin-deficient plants. Proc. Natl. Acad. Sci., USA, 1999, 96, 12923-12928. 

Haralampidis,K, Bryan, G, Qi, X, Papadopoulou, K, Bakht, S, Melton, R and Osbourn, AE., A new class of oxidosqualene cyclases directs synthesis of antimicrobial phytoprotectants in monocots. Proc. Natl. Acad. Sci., USA, 2001, 98, 13431-13436. 

Haralampidis, K, Trojanowska, M and Osbourn, AE, Biosynthesis of triterpenoid saponins in plants. Adv. Biochem. Eng./Biotechnology, 2001, 75, 31-49

Inositol Research Group at the School of Biological Sciences, UEA

F.Lemtiri-Chlieh, E.A.MacRobbie & CA.Brearley, Inositol hexakisphosphate is a physiological signal regulating the K+-inward rectifying conductance in guard cells. Proc. Nat.l Acad. Sci. USA., 2000, 97, 8687-8692.

CA.Brearley & DE.Hanke, Metabolic relations of inositol 3,4,5,6-tetrakisphosphate revealed by cell permeabilization. Identification of inositol 3,4,5, 6-tetrakisphosphate 1-kinase and inositol 3,4,5,6-tetrakisphosphate phosphatase activities in mesophyll cells. Plant Physiol., 2000, 122, 1209-1216.

C.A.Brearley and D.E.Hanke, Inositol phosphates in barley (Hordeum vulgare L) aleurone tissue are stereochemically similar to the products of breakdown of InsP6 in vitro by wheat-bran phytase Biochem. J., 1996, 318,279-286.

 
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